OPRK_HUMAN

General information

OPRK_HUMAN
Gene Name	OPRK1,OPRK
Family	Opioid type K
GPCRDB	OPRK_HUMAN
UniProt	P41145
IUPHAR	2409
Entrez Gene	4986
KEGG	hsa:4986
Sequence	OPRK_HUMAN.fasta

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Binding information

Agonist

L000038
	Name(s)	H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-D-PRO-LYS-OH TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-D-PRO-LYS [D-Pro10]- dyn (1-11)
	PubChem Compound
	Formula	C63 H103 N21 O13
	Mol. Wt.	1361.803
	Cas No.
	KEGG
	ChEBI
	DrugBank
	Struct. file	L000038.mol L000038.kegg
	Activity	Agonist
	Reference

L000184
	Name(s)	enadoline
	PubChem Compound	60768
	Formula	C24 H32 N2 O3
	Mol. Wt.	396.241
	Cas No.	124378-77-4
	KEGG
	ChEBI
	DrugBank
	Struct. file	L000184.mol L000184.kegg
	Activity	Full Agonist
	Reference	PMID:2178014 PMID:14613319

L000214
	Name(s)	Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
	PubChem Compound	5462471
	Formula	C26 H35 N5 O6
	Mol. Wt.	513.258
	Cas No.	78123-71-4
	KEGG	C11318
	ChEBI
	DrugBank
	Struct. file	L000214.mol L000214.kegg
	Activity	Partial Agonist
	Reference	PMID:9686407

L000238
	Name(s)	EMD 61753
	PubChem Compound	179340
	Formula	C27 H30 N2 O2
	Mol. Wt.	414.230
	Cas No.	153205-46-0
	KEGG
	ChEBI
	DrugBank
	Struct. file	L000238.mol L000238.kegg
	Activity	Agonist
	Reference

L000466
	Name(s)	PD 117302
	PubChem Compound	122115
	Formula	C21 H28 N2 O S
	Mol. Wt.	356.192
	Cas No.	111728-01-9
	KEGG
	ChEBI
	DrugBank
	Struct. file	L000466.mol L000466.kegg
	Activity	Agonist
	Reference

L000607
	Name(s)	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
	PubChem Compound	68616
	Formula	C19 H26 N2 O Cl2
	Mol. Wt.	368.142
	Cas No.	67198-13-4
	KEGG
	ChEBI
	DrugBank
	Struct. file	L000607.mol L000607.kegg
	Activity	Partial Agonist
	Reference	PMID:9686407 PMID:7869844 PMID:7624359 PMID:9262330 PMID:14718611 PMID:8114680 PMID:15383632

L000608
	Name(s)	spiradoline
	PubChem Compound	55652
	Formula	C22 H30 N2 O2 Cl2
	Mol. Wt.	424.168
	Cas No.	87151-85-7
	KEGG
	ChEBI
	DrugBank
	Struct. file	L000608.mol L000608.kegg
	Activity	Agonist
	Reference	PMID:8114680

L000609
	Name(s)	U 69593
	PubChem Compound	105104
	Formula	C22 H32 N2 O2
	Mol. Wt.	356.246
	Cas No.	96744-75-1
	KEGG
	ChEBI
	DrugBank
	Struct. file	L000609.mol L000609.kegg
	Activity	Full Agonist
	Reference	PMID:2986999 PMID:9686407 PMID:7624359 PMID:8114680 PMID:15054115 PMID:15952771

L000697
	Name(s)	etonitazene
	PubChem Compound	13493
	Formula	C22 H28 N4 O3
	Mol. Wt.	396.216
	Cas No.	911-65-9
	KEGG
	ChEBI
	DrugBank
	Struct. file	L000697.mol L000697.kegg
	Activity	Partial Agonist
	Reference	PMID:9686407

L000741
	Name(s)	salvinorin A
	PubChem Compound	128563
	Formula	C23 H28 O8
	Mol. Wt.	432.178
	Cas No.	83729-01-5
	KEGG
	ChEBI
	DrugBank
	Struct. file	L000741.mol L000741.kegg
	Activity	Full Agonist
	Reference	PMID:12192085 PMID:15869877 PMID:15383632 PMID:15952771