MC4R_HUMAN

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Agonist

Name(s) ACTH
ACTH18-39
adrenocorticotropic hormone(18-39)
corticotropin-like intermediate lobe peptide
PubChem Compound  
Formula C112 H165 N27 O36
Mol. Wt. 2464.188
Cas No. 67224-41-3 
KEGG  
ChEBI  
DrugBank  
Struct. file L000092.mol 
Activity Agonist
Reference
Name(s) MTII
muscarinic toxin 2
PubChem Compound  
Formula C50 H71 N15 O10
Mol. Wt. 1041.550
Cas No.  
KEGG  
ChEBI  
DrugBank  
Struct. file L000422.mol  L000422.kegg
Activity Agonist
Reference
Name(s) Ac-Ser-Tyr-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH
MSH, 4-Nle-7-Phe-alpha-
NDP-MSH
[Nle(4),D-Phe(7)]-alpha-MSH
PubChem Compound  
Formula
Mol. Wt.
Cas No. 75921-69-6 
KEGG  
ChEBI  
DrugBank  
Struct. file L000436.mol  L000436.kegg
Activity Full Agonist
Reference PMID:6777774 PMID:11101306 PMID:10493100 PMID:7774675 PMID:15840392
Name(s) Ro273225
PubChem Compound  
Formula
Mol. Wt.
Cas No.  
KEGG  
ChEBI  
DrugBank  
Struct. file L000514.mol  L000514.kegg
Activity Agonist
Reference
Name(s) MSH (11-13)
PubChem Compound 125672
Formula C16 H30 N4 O4
Mol. Wt. 342.226
Cas No. 67727-97-3 
KEGG  
ChEBI  
DrugBank  
Struct. file L000639.mol  L000639.kegg
Activity Full Agonist
Reference PMID:11101306 PMID:10493100
Name(s) beta-MSH
indicine
PubChem Compound 114843
Formula C15 H25 N O5
Mol. Wt. 299.173
Cas No. 10285-06-0 1414-01-3 
KEGG C10330
ChEBI  
DrugBank  
Struct. file L000642.mol  L000642.kegg
Activity Agonist
Reference
Name(s) melanotan-II
PubChem Compound 92432
Formula C50 H69 N15 O9
Mol. Wt. 1023.539
Cas No. 121062-08-6 
KEGG  
ChEBI  
DrugBank  
Struct. file L000966.mol  L000966.kegg
Activity Full Agonist
Reference PMID:2535874 PMID:11101306 PMID:10493100
no data Name(s) (1R,4S,6R)-N-((1R)-2-(4-cyclohexyl-4-(((1,1-dimethylethyl)amino)carbonyl)-1-piperidinyl-1-
 ((4-fluorophenyl)methyl)-2-oxoethyl)-2-methyl-2-azabicyclo(2.2.2)octane-6-carboxamide)
PubChem Compound  
Formula
Mol. Wt.
Cas No.  
KEGG  
ChEBI  
DrugBank  
Struct. file
Activity Full Agonist
Reference PMID:15982875
no data Name(s) THIQ
PubChem Compound  
Formula
Mol. Wt.
Cas No.  
KEGG  
ChEBI  
DrugBank  
Struct. file
Activity Full Agonist
Reference PMID:12361385

Antagonist

no data Name(s) AGRP
agouti-related protein
PubChem Compound  
Formula
Mol. Wt.
Cas No.  
KEGG  
ChEBI  
DrugBank  
Struct. file
Activity Inverse Agonist
Reference PMID:9299416